COMPOUNDS THAT MODULATE TRH ACTIONS AND INHIBIT THE TRH-DEGRADING ENZYME

摘要

The invention relates to compounds that inhibit thyrotropin-releasing hormone (TRH)- degrading ectoenzyme and/or enhance, and/or mimic the biological actions of TRH. The compounds find therapeutic application, particularly in conditions involving neuronal cell injury and disturbances in neurobiological function. These compounds are based on a C-terminally extended TRH-structure, wherein the C-terminal extension mainly consists of (D) amino acids.