| 摘要 |
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure. |
| 主权项 |
1. A method for evaluating renal status in a subject, comprising:
determining a measured value for one or more of a urine TIMP2 concentration and a urine IGFBP7 concentration; determining a measured value for one or more of a serum creatinine concentration and a urine output; combining the measured values obtained into a single value to provide an assay result; and correlating the assay result to the renal status of the subject, wherein said correlation step comprises correlating the assay result(s) to one or more of diagnosis, risk stratification, prognosis, classifying and monitoring of the renal status of the subject. |
