METHODS AND SYSTEMS FOR PROCESSING SAMPLES ON POROUS SUBSTRATES

摘要

Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.

主权项

1. A method for processing samples fixed to a porous substrate comprising,
receiving a patient sample on a porous substrate; inserting the porous substrate in a compression device creating a compression seal around only a portion of the porous substrate using the compression device to form an isolation zone within which a portion of the patient sample is thereby isolated; applying a fluid to the sample isolated in the isolation zone to move the fluid through the sample, wherein applying the fluid comprises applying the fluid to a surface of the porous substrate in the isolation zone; collecting at least a portion of the fluid after the fluid is applied to the isolation zone; and analyzing the collected fluid or the portion of the sample in the isolation zone.