| 发明名称 |
4H-PYRAN COMPOUNDS AS INSULIN-REGULATED AMINOPEPTIDASE (IRAP) INHIBITORS |
| 摘要 |
The present disclosure relates to 4H-pyran compounds of formula (I) and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosure further relates to said compounds and compositions thereof as inhibitors of IRAP and their use in the treatment or prevention of Alzheimer's disease and the treatment and prevention of memory and cognitive disorders. |
| 申请公布号 |
WO2016179645(A1) |
申请公布日期 |
2016.11.17 |
| 申请号 |
WO2016AU50332 |
申请日期 |
2016.05.06 |
| 申请人 |
MONASH UNIVERSITY;THE FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH;ST. VINCENT'S INSTITUTE OF MEDICAL RESEARCH |
发明人 |
CHAI, Siew Yeen;THOMPSON, Philip;MOUNTFORD, Simon;PARKER, Michael W. |
| 分类号 |
C07D309/32;A61K31/35;A61K31/351;A61K31/352;A61P25/28;C07D311/74;C07D311/94;C07D407/04;C07D407/10;C07D493/04 |
主分类号 |
C07D309/32 |
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