| 发明名称 |
HER2 BINDERS |
| 摘要 |
Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents. |
| 申请公布号 |
US2016199521(A1) |
申请公布日期 |
2016.07.14 |
| 申请号 |
US201615083424 |
申请日期 |
2016.03.29 |
| 申请人 |
General Electric Company ;AFFIBODY AB |
发明人 |
Syud Faisal Ahmed;Lee Brian Duh-Lan;Zhang Rong;Iveson Peter Brian;Schaffer Paul;Simonsson Tove;Gunneriusson Elin;Frejd Fredrik;Abrahmsen Lars;Feldwisch Joachim;Herne Nina;Lendel Christofer |
| 分类号 |
A61K51/08 |
主分类号 |
A61K51/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of imaging at least a portion of a subject comprising:
administering a composition to the subject, wherein the composition comprising an isolated polypeptide comprising SEQ. ID No. 1, SEQ. ID No. 2, or a conservative variant thereof, conjugated with a 99mTc via a diaminedioxime chelator, and wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and imaging the subject with a diagnostic device. |
| 地址 |
Schenectady NY US |
