Methods related to immunostimulatory nucleic acid-induced interferon

摘要

Methods and compositions are provided for extending the clinical utility of IFN-alpha in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-alpha treatment and reduce IFN-alpha treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.