DELIVERY OF MICRORNA USING MESENCHYMAL STEM CELL MICROPARTICLES

摘要

MIRNAs have been implicated in the development of some if not all cancer types and have been identified as attractive targets for therapy. However, systemic delivery of miRNAs faces its own set of limitations because of degradation by RNases and filtration and excretion by the kidneys. In this work we propose a new class of therapeutic agents, based on microparticles (MPs) derived from mesenchymal stem cells (MSCs) that can selectively target tumors in vivo, containing and delivering miRNAs that affect the action of genes associated with cancer growth, neovascularization and metastasis applicable to both local and systemic administration.