NOVEL QUINOLINE -SUBSTITUTED COMPOUND

摘要

An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects.;The present invention provides a compound represented by Formula (I) below, or a salt thereof.;

主权项

1. A compound represented by Formula (I) below or a salt thereof: wherein the group: is (1) a group represented by Formula A1: (in Formula A1, B is a group represented by: [R1 is a hydrogen atom or a C1-C6 alkyl group; and R2 is a group represented by: wherein R3, R4, and R5 are the same or different, and each represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a C6-C12 aryl group, a C4-C9 heteroaryl group, an aminomethyl group that may be substituted with a C1-C6 alkyl group, or a 1-piperidinomethyl group,
or a group represented by: wherein R6 represents a hydrogen atom or a C1-C6 alkyl group],
R7 and R8 are the same or different, and each represents a hydrogen atom or a C1-C6 alkyl group; m is 0 or 1; and n is 1 or 2);(2) a group represented by Formula A2: (in Formula A2, B and n are as defined in Formula A1; and R9 is a hydrogen atom or a C1-C6 alkyl group); or
(3) a group represented Formula A3: (in Formula A3, B, m, and n are as defined in Formula A1; and R10 is a C1-C6 alkyl group).