SULFATED AND UNSULFATED FLAVONOID OLIGOMERS AS CANCER THERAPEUTICS

摘要

Sulfated and unsulfated flavonoid oligomers as inhibitors of cancer stem cells (CSCs) are provided. In particular, sulfated flavonoid dimers are shown to selectively inhibit CSCs growth and self-renewal both in vitro and in vivo.

主权项

1. Sulfated flavonoid dimers having the general formula of formula I: wherein R is one or more of —OH, or —OSO3−M+ or —H, each of which may be the same or different, wherein at least one —OSO3−M+ group is present in the molecule and wherein M is selected from the group consisting of Na+, K+, Li+, NH4+, NR′4+, Mg2+, Ca2+ or other metal cations, wherein R′ is H or alkyl or aryl groups; L is any one of linkers L1 through L9 shown below wherein n is 1-10; and the two flavonoid units are connected through either 5-5, 5-6, 5-7, 5-8, 6-6, 6-7, 6-8, 7-7, 7-8, or 8-8 linkages.