| 主权项 |
1. Compound of the following formula (I): wherein: X represents NH, O, S or CH2; n represents an integer comprised from 3 to 7, n being in particular equal to 5; Y represents a group selected from: Z representing O, S or NH; R representing:
H,a linear or branched (C1-C7)-alkyl, in particular methyl, ethyl, isopropyl or isobutyl,a group of formula —(CH2)i—X′—(CH2)j—H, wherein X′ represents O, S or NH, i is an integer from 1 to 7, and j is an integer from 0 to 7, said group being in particular —CH2—O—CH3,a linear or branched (C2-C7)-alkenyl,a linear or branched (C2-C7)-alkynyl,a (C3-C7)-cycloalkyl,a (C5-C7)-cycloalkenyl,a (C3-C7)-heterocycloalkyl,a (C5-C7)-heterocycloalkenyl,an aryl, said aryl being an aromatic or heteroaromatic group,an alkyl aryl, wherein the aryl is an aromatic or heteroaromatic group,a CO—(C1-C7)-alkyl,a CO-aryl, wherein aryl is an aromatic or heteroaromatic group, a CO2H, a CO2—(C1-C7)-alkyl, a CONH—(C1-C7)-alkyl, CF3, adamantyl, CHRa—NH2, wherein Ra represents the side chain of a proteinogenic aminoacid, a cyclodextrin, said cyclodextrin being in particular chosen from α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) and their derivatives, in particular alkylated α-cyclodextrins, alkylated β-cyclodextrins and alkylated γ-cyclodextrins, said cyclodextrin being more particularly a β-cyclodextrin, even more particularly a cyclodextrin of one of the following formulae: said (C1-C7)-alkyl, group of formula —(CH2)i—X′—(CH2)j—H, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C3-C7)-cycloalkyl, (C5-C7)-cycloalkenyl, (C3-C7)-heterocycloalkyl, (C5-C7)-heterocycloalkenyl, CO—(C1-C7)-alkyl, CO2—(C1-C7)-alkyl, CONH—(C1-C7)-alkyl, aryl, alkyl aryl, CO-aryl and cyclodextrin being substituted or not by one or more substituent(s), each independently selected from:
a linear or branched (C1-C7)-alkyl,a linear or branched (C2-C7)-alkenyl,a linear or branched (C2-C7)-alkynyl,a (C3-C7)-cycloalkyl,a (C5-C7)-cycloalkenyl,a (C3-C7)-heterocycloalkyl,a (C5-C7)-heterocycloalkenyl,an aryl, wherein the aryl is an aromatic or heteroaromatic groupan alkyl aryl, wherein the aryl is an aromatic or heteroaromatic group,a CHO,a CO—(C1-C7)-alkyl,a CO-aryl, wherein aryl is an aromatic or heteroaromatic group,a CO2H,a CO2—(C1-C7)-alkyl,a CONH—(C1-C7)-alkyl,a halogen selected from the group comprising F, Cl, Br, and I,CF3,ORa, wherein Ra represents:
H, a linear or branched (C1-C7)-alkyl, a (C3-C7)-cycloalkyl, CO—(C1-C7)-alkyl, or CO-aryl, wherein aryl is an aromatic or heteroaromatic group,NRbRc, wherein Rb and Rc represent independently from each other:
H, a linear or branched (C1-C7)-alkyl, a (C3-C7)-cycloalkyl, CO—(C1-C7)-alkyl, or CO-aryl, wherein aryl is an aromatic or heteroaromatic group,NO2,CN,SO3H or one of its salts, in particular SO3Na; and its pharmaceutically acceptable salts, provided that when R represents CHRa—NH2, then Y can only represent the following group (a): for use in the treatment or the prevention of inflammatory bowel disease, in particular Crohn disease or ulcerative colitis. |
