ANTI-MESOTHELIN BINDING PROTEINS

摘要

The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

主权项

1. An isolated anti-mesothelin human antibody or antigen binding protein or fragment thereof, wherein said antibody has at least one or more of the properties selected from the group consisting of:
a) binds to a different epitope than the MORAb-009 antibody; b) competes for binding with Ab237; c) specifically binds to human, cynomolgus, rat and murine mesothelin; d) does not internalize upon binding to mesothelin; e) when bound to mesothelin, does not inhibit CA125 interaction with mesothelin; f) has a binding affinity KD of at least 5.0 pM against human mesothelin; g) has enhanced effector function; h) binds to membrane-bound mesothelin preferentially over soluble mesothelin; and i) reduces the growth of mesothelin expressing tumor cells in vivo.