| 发明名称 |
ANTI-TRANSTHYRETIN HUMAN ANTIBODY |
| 摘要 |
A human antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The human antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a human antibody suitable for application to human body. |
| 申请公布号 |
US2016340419(A1) |
申请公布日期 |
2016.11.24 |
| 申请号 |
US201515114545 |
申请日期 |
2015.01.23 |
| 申请人 |
THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
TORIKAI Masaharu;HOSOI Akihiko;TAKEO Tomoyo;UENO Masayo;SOEJIMA Kenji;NAKASHIMA Toshihiro;ANDO Yukio;JONO Hirofumi;SU Yu;MIZUGUCHI Mineyuki |
| 分类号 |
C07K16/18;G01N33/68 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A human antibody having the activity to inhibit fibrillization of transthyretin (hereinafter referred to as “TTR”). |
| 地址 |
Kumamoto-shi JP |
