| 主权项 |
1. A compound of formula (I) wherein n is 0 or 1; X is O or S; Y is a CO group or a CH2 group or a bond;
R2 and R3 are independently H or an alkyl, cycloalkyl, heteroalkyl or heterocycloalkyl group, all of which may optionally be substituted, or R2 and R3 together are a group of formula (CH2)m wherein m is 2, 3, 4 or 5; R4 is H, an alkyl, cycloalkyl, heteroalkyl or heterocycloalkyl group, all of which may optionally be substituted; R5 is H, an alkyl, cycloalkyl, heteroalkyl or heterocycloalkyl group, all of which may optionally be substituted; R6 is H, an alkyl, alkenyl, alkynyl, heteroalkyl, aralkyl or heteroaralkyl group, all of which may optionally be substituted; R7 is H, an alkyl, alkenyl, alkynyl, heteroalkyl, aralkyl or heteroaralkyl group, all of which may optionally be substituted; R8 is H, an alkyl, heteroalkyl group, aralkyl or heteroaralkyl group, all of which may optionally be substituted; and either R1 is H, a heteroalkyl group or a group of formula —X1-L1-A1 or —X1—CH2—CH2—S—S-Py, wherein Py is a 2-pyridyl group; and R9 is H, OH, SH, CN, NH2, NO2, halogen, or an alkyl, heteroalkyl, aryl, heteroaryl, aryloxy or heteroaryloxy group, all of which may optionally be substituted; and R10 is OH, NH2, NHNH2, O—NH2, or a heteroalkyl, heteroaryl, aryloxy, aralkyloxy, heteroaralkyloxy or heteroaryloxy group, all of which may optionally be substituted; or R1 is H, an alkyl group or a heteroalkyl group, all of which may optionally be substituted; and R9 is H, OH, SH, CN, NH2, NO2, halogen, or an alkyl, heteroalkyl, aryl, heteroaryl, aryloxy or heteroaryloxy group, all of which may optionally be substituted; and R10 is a group of formula —X2-L2-A2 or —X2—CH2—CH2—S—S-Py, wherein Py is a 2-pyridyl group or, if Y is a bond, a heteroaryl group; or R1 is H, an alkyl group or a heteroalkyl group, all of which may optionally be substituted; and R9 is a group of formula —X3-L3-A3 or —X3—CH2—CH2—S—S-Py, wherein Py is a 2-pyridyl group; and R10 is OH, NH2, NHNH2, O—NH2, or a heteroalkyl, heteroaryl, aryloxy, aralkyloxy, heteroaralkyloxy or heteroaryloxy group, all of which may optionally be substituted; X1 is a bond or —CO—O—, —CO—, —NH— or —NHCO—O—; X2 is —NH—NH—CO—O—, —NH—NH—CO—S—, —NH—NH—CO—NH—, —NH—CO—, —NH—NH—, —O—, —O—NH—, —S— or —NH—; X3 is —O—, —S—, —NH—, —O—NH—, —O—CO—NH—, —O—CO—, —NH—CO—, —NH—CO—O—, —NH—CO—NH—, —NHNHCO—O—, —NHNHCO—S— or —NHNHCO—NH—; L1 is a linear, optionally substituted alkylene group containing from 1 to 20 carbon atoms in the chain or a linear, optionally substituted heteroalkylene group containing from 1 to 50 carbon atoms in the chain and from 1 to 20 oxygen, sulfur and/or nitrogen atoms, wherein this linear alkylene or heteroalkylene group may contain in its chain one or more arylene or heteroarylene group(s); L2 is a linear, optionally substituted alkylene group containing from 1 to 20 carbon atoms in the chain or a linear, optionally substituted heteroalkylene group containing from 1 to 50 carbon atoms in the chain and from 1 to 20 oxygen, sulfur and/or nitrogen atoms, wherein this linear alkylene or heteroalkylene group may contain in its chain one or more arylene or heteroarylene group(s); L3 is a linear, optionally substituted alkylene group containing from 1 to 20 carbon atoms in the chain or a linear, optionally substituted heteroalkylene group containing from 1 to 50 carbon atoms in the chain and from 1 to 20 oxygen, sulfur and/or nitrogen atoms, wherein this linear alkylene or heteroalkylene group may contain in its chain one or more arylene or heteroarylene group(s); A1 is OH, SH, NH2, N3 or NH—C1-6alkyl, a group of formula —NH—CO—CH2—NH—(CO—CH2—NH—)wCO—CH2—NH2r or a C2-C6 alkynyl group or an optionally substituted heteroaryl group or an optionally substituted heterocycloalkyl group or an optionally substituted heteroalkylcycloalkyl group or an optionally substituted heteroaralkyl group or an optionally substituted aryl group or an optionally substituted aralkyl group, wherein w is an integer of from 1 to 5; and A2 is OH, SH, NH2, N3 or NH—C1-6alkyl, a group of formula —NH—CO—CH2—NH—(CO—CH2—NH—)wCO—CH2—NH2, or a C2-C6 alkynyl group or an optionally substituted heteroaryl group or an optionally substituted heterocycloalkyl group or an optionally substituted heteroalkylcycloalkyl group or an optionally substituted heteroaralkyl group or an optionally substituted aryl group or an optionally substituted aralkyl group, wherein w is an integer of from 1 to 5; A3 is OH, SH, NH2, N3 or NH—C1-6alkyl, a group of formula —NH—CO—CH2—NH—(CO—CH2—NH—)wCO—CH2—NH2, or a C2-C6 alkynyl group or an optionally substituted heteroaryl group or an optionally substituted heterocycloalkyl group or an optionally substituted heteroalkylcycloalkyl group or an optionally substituted heteroaralkyl group or an optionally substituted aryl group or an optionally substituted aralkyl group, wherein w is an integer of from 1 to 5; or a pharmacologically acceptable salt, solvate or hydrate thereof. |
