发明名称 |
HUMAN MICRORNA TARGETS IN HIV GENOME AND A METHOD OF IDENTIFICATION THEREOF |
摘要 |
The present invention relates to human microRNA targets in HIV genome and a method of identification thereof. Using multiple software targets to six human microRNAs [miRNAs] were discovered in the nef, vpr, env, and I vif genes. The miRNAs were identified as hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-mir-149, hsa-mir-324-5p, hsa-mir-378. These miRNAs or its homologues can be used as therapeutics against HIV infection. The invention further relates to a novel strategy to target genes of HIV-1 by human microRNAs, or its homologues, to inactivate or block HIV activity. The computational approach towards identification of human miRNA targets in the HIV genome and the variation in the microRNA levels was further validated experimentally. |
申请公布号 |
WO2007042899(A2) |
申请公布日期 |
2007.04.19 |
申请号 |
WO2006IB02802 |
申请日期 |
2006.10.09 |
申请人 |
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH;BRAHMACHARI, SAMIR, KUMAR;HARIHARAN, MANOJ;SCARIA, VINOD;PILLAI, BEENA |
发明人 |
BRAHMACHARI, SAMIR, KUMAR;HARIHARAN, MANOJ;SCARIA, VINOD;PILLAI, BEENA |
分类号 |
A61K31/7088;C12N15/11;C12N15/113;G06F19/18;G06F19/22 |
主分类号 |
A61K31/7088 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|