| 发明名称 |
Whole-Cell System For Cytochrome P450 Monooxygenases Biocatalysis |
| 摘要 |
The subject of the present invention is a whole-cell catalysis process for converting substrates of cytochrome P450 monooxygenases of eukaryotic origin into valuable biotechnological products. The subject of the present invention is also microorganisms genetically engineered to achieve those biotransformations with high rates and processes to prepare these microorganism strains. |
| 申请公布号 |
US2016376625(A1) |
申请公布日期 |
2016.12.29 |
| 申请号 |
US201414898655 |
申请日期 |
2014.06.17 |
| 申请人 |
SANOFI |
发明人 |
Gerber Adrian;Hannemann Frank;Bleif Sabrina;Kleser Michael;Bernhardt Rita |
| 分类号 |
C12P33/16;C12N9/10;C12N9/02 |
主分类号 |
C12P33/16 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A genetically engineered microorganism capable of convening cholesterol, cholesterol analogs and derivatives into steroid hormones precursors, wherein said microorganism comprises at least one DNA sequence encoding a cytochrome P450 of eukaryotic origin, an exogenous DNA sequence encoding Adx and an exogenous DNA sequence encoding AdR. |
| 地址 |
Paris FR |
