| 摘要 |
The invention is a method for coating an implantable medical device The surface of the substrate used, in the raw condition, following cleaning and physiochemical pretreatments, is coated using a biomimetic process in a supersaturated calcium phosphate solution (SCPS) to obtain the desired coating coverage and morphology maintaining a ratio of calcium to phosphorus pH, as well as solution temperature plays a major role in yielding precipitation of the proper phase of CaP so that composition, morphologies, crystal structures, and solubility characteristics are optimal for the deposition process The biomimetic coating adds osteoconductivity, to maximize bone growth This attribute is acquired by using therapeutic agents (bone morphogeny proteins, growth factors, stem cells, etc) The therapeutic agents are co-precipitated and bonded with the CaP directly A dipping process into BMP provides an initial burst of cellular activity Optionally stem and/or progenitor cells are cultured on the surface of the implant
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