| 发明名称 |
INERTIO-ELASTIC FOCUSING OF PARTICLES IN MICROCHANNELS |
| 摘要 |
One example of systems and methods for inertio-elastic focusing of particles in microchannels includes a substrate including a channel having an inlet and an outlet. A viscoelastic fluid, i.e., a fluid having a dynamic viscosity that varies with shear rate, and that carries suspended particles is driven through the channel. The volumetric flow rate at which the fluid is driven results in the formation of a localized pathline in the fluid at or near a center of the channel. The localized pathline defines a width that is equal to or slightly greater than a hydraulic diameter of the particle. The particles in the fluid are focused into the localized pathline. |
| 申请公布号 |
US2016339434(A1) |
申请公布日期 |
2016.11.24 |
| 申请号 |
US201515114050 |
申请日期 |
2015.01.30 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION ;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
Toner Mehmet;McKinley Gareth;Lim Eugene;Ober Thomas |
| 分类号 |
B01L3/00 |
主分类号 |
B01L3/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for focusing particles suspended within a moving fluid, the method comprising:
providing a substrate including a channel having an inlet and an outlet; and driving a fluid having a dynamic viscosity that varies with shear rate and that carries suspended particles through the channel at a volumetric flow rate that results in the formation of a localized pathline in the fluid at or near a center of the channel, wherein the localized pathline defines a width that is substantially equal to or greater than a hydraulic diameter of the particle, wherein the particles in the fluid are focused into the localized pathline. |
| 地址 |
Boston MA US |
