发明名称 |
PROPANE-1,3-DION DERIVATIVE OR SALT THEREOF |
摘要 |
It is intended to provide a compound useful as a GnRH receptor antagonist. The inventors further investigated propane-1,3-dione derivatives. As a result, they confirmed that a compound having a benzene ring or a thiophene ring substituted with a group represented by -SO 2 -R 3 in a propane-1,3-dione derivative having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene) has an excellent GnRH receptor antagonistic effect and accomplished the present invention. Because the compound of the present invention has a potent GnRH receptor antagonistic effect, it is useful for the treatment of sex hormone-dependent diseases, particularly GnRH-related diseases. Further, because the compound of the present invention has an excellent metabolic stability in human and few drug interactions, therefore it has preferable characteristics as a pharmaceutical used for the above-mentioned diseases.
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申请公布号 |
EP1864976(A1) |
申请公布日期 |
2007.12.12 |
申请号 |
EP20060730589 |
申请日期 |
2006.03.30 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
MATSUMOTO, SHUNICHIRO;KINOYAMA, ISAO;OSODA, KAZUHIKO;YAMAMOTO, HIROFUMI;HIRANO, MASAAKI;OHNUKI, KEI;KAWAMINAMI, EIJI;SHIN, TAKASHI;TAKAHASHI, TATSUHISA;KUSAYAMA, TOSHIYUKI;HISAMICHI, HIROYUKI;SHIMADA, ITSURO;KOIKE, TAKANORI |
分类号 |
C07D235/12;A61K31/4184;A61K31/4192;A61K31/4196;A61P13/08;A61P35/00;C07D403/06;C07D409/14;C07D413/10 |
主分类号 |
C07D235/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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