发明名称 |
METHOD FOR PRODUCING BENZO[B] THIOPHENE COMPOUNDS |
摘要 |
The present invention provides a method for producing a compound of Formula (4): wherein R1 is a hydrogen atom etc. by reacting a compound of Formula (2): wherein X1 is a leaving group, with a compound of Formula (3): wherein R1 is as defined above, in the presence of (a) a palladium compound and a tertiary phosphine or (b) a palladium carbene complex, in an inert solvent or without a solvent. The present invention can produce the compound of Formula (4), with high purity and high yield, and by a simple operation. |
申请公布号 |
EP2736894(B1) |
申请公布日期 |
2016.08.31 |
申请号 |
EP20120748265 |
申请日期 |
2012.07.27 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
SHINHAMA, KOICHI;UTSUMI, NAOTO;SOTA, MASAHIRO;FUJIEDA, SHIGEO;OGASAWARA, SHIN |
分类号 |
C07D333/54;C07B61/00;C07D409/12 |
主分类号 |
C07D333/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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