发明名称 |
DE-IMMUNIZED, SHIGA TOXIN A SUBUNIT SCAFFOLDS AND CELL-TARGETING MOLECULES COMPRISING THE SAME |
摘要 |
The present invention relates to Shiga toxin A Subunit derived polypeptides and cell-targeting molecules comprising amino acid substitutions which equip the polypeptides with 1) de-immunization; 2) reduced, protease-cleavage sensitivity; and/or 3) a heterologous epitope cargo(s) while retaining Shiga toxin function(s), such as, e.g., potent cytotoxicity. Certain polypeptides of the invention exhibit reduced immunogenic potential in mammals and/or are capable of delivering an epitope to an MHC class molecule of a cell in which the polypeptide is present. Certain molecules comprising a polypeptide of the invention are well-tolerated by mammals while retaining one or more of the features mentioned above. The Shiga toxin polypeptides of the invention have uses as components of cell-targeting molecules for selectively killing specific cells; for selectively delivering cargos to specific cells, and as therapeutic and/or diagnostic molecules for treating and diagnosing a variety of conditions, including cancers, immune disorders, and microbial infections. |
申请公布号 |
WO2016196344(A1) |
申请公布日期 |
2016.12.08 |
申请号 |
WO2016US34778 |
申请日期 |
2016.05.27 |
申请人 |
MOLECULAR TEMPLATES, INC. |
发明人 |
POMA, Eric;WILLERT, Erin;ROBINSON, Garrett Lee;RAJAGOPALAN, Sangeetha;BRIESCHKE, Brigitte |
分类号 |
C07K14/25 |
主分类号 |
C07K14/25 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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