| 发明名称 |
Pharmaceutical Composition |
| 摘要 |
Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated. |
| 申请公布号 |
US2016375011(A1) |
申请公布日期 |
2016.12.29 |
| 申请号 |
US201615262420 |
申请日期 |
2016.09.12 |
| 申请人 |
Alpharma Pharmaceuticals LLC |
发明人 |
Liang Alfred;Matthews Frank;Boehm Garth;Tang Lijuan;Johnson Frank;Stauffer Joseph |
| 分类号 |
A61K31/485 |
主分类号 |
A61K31/485 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a condition in a host that is responsive to an agonist, the method comprising administering a multi-layer pharmaceutical composition comprising an agonist and an antagonist thereof that are not in direct contact with one another in the intact form of the composition, wherein administration of the intact form of the composition to the host once or twice daily for at least one week results in zero release of the antagonist. |
| 地址 |
Bridgewater NJ US |
