| 主权项 |
1. A compound of Formula (III), or a pharmaceutically acceptable salt, or solvate thereof: wherein, R1 is —Cl, —Br, —CN, or C3-C6cycloalkyl; R2 is H, halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(═O)R9, —S(═O)2R9, —S(═O)2N(R10)2, C1-C4alkyl, C1-C4fluoroalkyl, C1-C4deuteroalkyl, or C3-C6cycloalkyl; R3 is H, halogen, —CN, —OH, C1-C4alkyl, C1-C4fluoroalkyl, C1-C4deuteroalkyl, C1-C4alkoxy, or C1-C4fluoroalkoxy; W is CH, CF or N; each RA is H, halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(═O)R9, —S(═O)2R9, —S(═O)2N(R10)2, C1-C6alkyl, or C1-C6fluoroalkyl; L1 is absent, C1-C6alkylene, or C3-C6cycloalkylene; Q is —CO2H, —CO2(C1-C6alkyl), —OH, —CN, —B(OH)2, —C(═O)NHSO2R9, —C(═O)N(R10)2, —SO2NHC(═O)R9, —CN, tetrazolyl, —OP(═O)(OH)2, —P(═O)(OH)2 or carboxylic acid bioisostere; Ring B is a monocyclic heteroaryl;
each RB is independently H, halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(═O)R9, —S(═O)2R9, —S(═O)2N(R10)2, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted phenyl, C1-C4alkylene-(substituted or unsubstituted phenyl), substituted unsubstituted monocyclic heteroaryl, C1-C4alkylene-(substituted or unsubstituted monocyclic heteroaryl), a substituted or unsubstituted bicyclic heteroaryl, or C1-C4alkylene-(substituted or unsubstituted bicyclic heteroaryl); n is 0, 1, or 2; R9 is C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C3-C6cycloalkyl, a substituted or unsubstituted phenyl, a substituted or unsubstituted monocyclic heteroaryl, or a substituted or unsubstituted bicyclic heteroaryl; each R10 is independently H, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C3-C6cycloalkyl, a substituted or unsubstituted phenyl, or a substituted or unsubstituted monocyclic heteroaryl; or two R10 groups attached to the same N atom are taken together with the N atom to which they are attached to form a substituted or unsubstituted heterocycle. |
