HIV ENV PROTEINS WITH MODIFICATIONS IN THE V3 LOOP
摘要
<p>The invention concerns modification of the V3 loop of the HIV envelope glycoprotein in order to alter its Tat-binding properties. The invention provides a mixture of (i) a HIV Tat polypeptide and (ii) a HIV Env polypeptide, wherein the Env polypeptide has one or more mutations in its V3 loop. Also a method comprising a step of: combining a HIV Env polypeptide with a HIV Tat polypeptide, wherein the Env polypeptide has one or more mutations in its V3 loop. Also a mixture of (i) a HIV Tat polypeptide and (ii) a polypeptide comprising a fragment of a V3 loop of a HIV Env polypeptide.</p>
申请公布号
WO2009029569(A1)
申请公布日期
2009.03.05
申请号
WO2008US74179
申请日期
2008.08.25
申请人
NOVARTIS VACCINES AND DIAGNOSTICS INC.;BARNETT, SUSAN W.;LIAN, YING;SHARMA, VICTORIA;SRIVASTAVA, INDRESH K.
发明人
BARNETT, SUSAN W.;LIAN, YING;SHARMA, VICTORIA;SRIVASTAVA, INDRESH K.