发明名称 |
PROGNOSIS OF RESPONSE TO TREATMENT WITH ANTI-TNF-ALPHA IN PATIENTS WITH RHEUMATOID ARTHRITIS |
摘要 |
The invention relates to the use of SNP rs3794271, and/or an SNP that is in total linkage disequilibrium with same, as a marker in predicting the response to treatment with anti-TNF in a patient with RA. The invention also relates to methods for predicting the response to treatment with anti-TNF, as well as for deciding on or recommending a treatment for a patient with RA, based on determining the genotype for rs3794271 and/or an SNP that is in total linkage disequilibrium with same. |
申请公布号 |
US2016160279(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
US201514930607 |
申请日期 |
2015.11.02 |
申请人 |
Fundacio Hospital Universitari Vall D'Hebron- Institut De Recerca |
发明人 |
MARSAL BARRIL SARA;Julia Cano Antoni;Tornero Molina Jesus |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. An in vitro method for the prediction of the response of a patient with rheumatoid arthritis (RA) to treatment with tumor necrosis factor inhibitor alpha (anti-TNF alpha agent) selected between infliximab or etanercept that comprises determining, from a sample obtained from the patient, the genotype for single nucleotide polymorphism (SNP) rs3794271, and/or at least one SNP that is in linkage disequilibrium with SNP rs3794271, wherein:
i. the presence of at least one G allele at SNP rs3794271 is indicative of a bad response to treatment while the presence of two alleles other than G at SNP rs3794271 is indicative of a good response to therapy; and/or ii. the presence of at least one allele correlated with the G allele at SNP rs3794271 for the SNP in linkage disequilibrium is indicative of a bad response to treatment while the presence of two alleles not correlated with the G allele at SNP rs3794271 for the SNP in linkage disequilibrium is indicative of a good response to treatment. |
地址 |
Barcelona ES |