T CELL-INDUCING VACCINE CONTAINING INTEREPITOPE SEQUENCE PROMOTING ANTIGEN PRESENTATION

摘要

The purpose of the present invention is to provide an interepitope sequence that effectively induces antigen presentation of each epitopes in a long-chain peptide antigen having a plurality of epitopes. A vaccine for the purpose contains a long-chain peptide antigen having a plurality of epitopes, said vaccine being characterized in that a sequence between the individual epitopes is one sequence selected from the group consisting of two to ten consecutive tyrosines, two to ten consecutive threonines, two to ten consecutive alanines, two to ten consecutive histidines, two to ten consecutive glutamines and two to ten consecutive asparagines. It is preferred that the vaccine is one selected from the group consisting of an anticancer vaccine, an antibacterial vaccine and an antiviral vaccine. It is also preferred that the vaccine is at least one selected from the group consisting of a peptide vaccine, a DNA vaccine, an mRNA vaccine and a dendritic cell vaccine.