| 摘要 |
PROBLEM TO BE SOLVED: To provide a solution to a long-standing clinical problem of autoimmunity, allergy/asthma, in vivo chronic or inadequate inflammation, for example, the inflammation causing tissue/organ damage and disruption.SOLUTION: The invention provides a scaffold composition containing an antigen, recruitment composition, and tolerogen that recruit immunocytes and promote its activation to an anti-inflammatory phenotype, using in vivo biomaterial systems, for example a gel scaffold, to cause inhibition of inflammation. The composition preferably contains a Th1 promoting agent. The tolerogen contains thymic stromal lymphopoietin, dexamethasone, vitamin D, retinoic acid, rapamycin, aspirin, transforming growth factor β, interleukin 10, vascular endothelial growth factor, and the like. The recruitment composition contains GM-CSF, FMS-like tyrosine kinase 3 ligand, N-formyl peptide, fractalkine, or monocyte-chemoattractant-protein-1. The composition is useful for reducing the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.SELECTED DRAWING: None |
