发明名称 |
Anti-C5 Antibodies and Methods of Use |
摘要 |
An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the β chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the β chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament. Anti-C5 antibodies of the present invention may be for use in treating a complement-mediated disease or condition which involves excessive or uncontrolled activation of C5. Anti-C5 antibodies of the present invention may be for use in enhancing the clearance of C5 from plasma. |
申请公布号 |
US2016176954(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
US201514974350 |
申请日期 |
2015.12.18 |
申请人 |
Chugai Seiyaku Kabushiki Kaisha |
发明人 |
RUIKE Yoshinao;Sampei Zenjiro |
分类号 |
C07K16/18;G01N33/564 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated antibody that binds to C5, wherein the antibody binds to an epitope within the β chain of C5 with a higher affinity at neutral pH than at acidic pH. |
地址 |
Tokyo JP |