Ang-2 Binding Complexes and Uses Thereof

摘要

Complexes containing one or more modular recognition domains (MRDs) and MRDs attached to scaffolds including antibodies are described. The manufacture of these complexes are the use of these complexes to treat and diagnose diseases and disorders are also described.

主权项

1. A complex comprising a modular recognition domain (MRD) capable of binding ANG-2, wherein the MRD comprises an amino acid sequence having the formula X1X2X3X4X5X6MPMDX11X12EX14X15LYEX19X20X21X22 (SEQ ID NO: 125) and wherein:
X1 is 1-10 amino acid residues; X2 is L, A, V, P, I, W, F, M, S, N, E, G, T, H, Y, or C; X3 is N, Q, G, S, T, E, D, Y, M, V, L, or I; X4 is N, Q, G, S, T, Y, F, E, P, A, or H; X5 is N, Q, G, S, T, Y, E, H, L, A, V, P, I, W, F, or M; X6 is V, M, A, F, L, P, I, W, or Y; X11 is Q, G, S, T, Y, L, V, P, I, W, F, M, K, R, or H; X12 is D, E, N, Q, G, S, T, Y, P, W, K, R, or H; X14 is A, D, N, G, S, T, Y, V, P, I, W, F, M, K, R, or H; X15 is V, M, A, F, L, P, I, W, Y, D, E, T, H, or Norleucine; X19 is A, E, D, G, S, T, Y, L, V, P, I, W, F, M, K, R, or H; X20 is E, D, V, M, A, F, L, P, I, W, Y, K, R, H, or Norleucine; X21 is V, M, A, F, L, P, I, W, C, Y, or Norleucine; and X22 is 1-10 amino acid residues.