发明名称 |
METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES |
摘要 |
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to the targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof. |
申请公布号 |
US2016176916(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
US201514707930 |
申请日期 |
2015.05.08 |
申请人 |
Dana-Farber Cancer Institute, Inc. |
发明人 |
Bradner James;Buckley Dennis;Winter Georg |
分类号 |
C07J43/00;C07D401/14;C07D471/04;C07D495/14;C07D487/04 |
主分类号 |
C07J43/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Boston MA US |