PROCESS FOR THE PREPARATION OF PERAMPANEL

摘要

The present invention provides intermediates useful for the synthesis of Perampanel and processes employing said intermediates for preparing Perampanel. The invention also provides processes for making the intermediates, crystalline forms of the intermediates and the use of the crystalline forms for preparing Perampanel.

主权项

1. Use of the compound of Formula II of the following structure: or salts thereof, in the preparation of Perampanel or a salt thereof, wherein: X is oxygen or a NR2R3 group, wherein R2 and R3 are independently selected from: a C1-C15 straight or branched alkyl group, a C1-C10 cycloalkyl group, an optionally substituted C6-C10 aryl group and an optionally substituted C7-C12 arylalkyl group; and Z is a leaving group; preferably wherein Z is a NR2R3 group where R2 and R3 are as defined above, OH, halogen, alkoxy, methanesulfonyl, or p-toluenesulfonyl.