GENIC SEQUENCE ENCODING A TCR SPECIFIC FOR THE HUMAN MHC CLASS I COMPLEX SPECIFIC FOR THE HLA-AO2 COMPLEX AND THE PEPTIDE HTERT865-873, AS WELL AS ITS USE IN THE ENGINEERING OF T LYMPHOCYTES FOR POSSIBILE CLINICAL APPLICATIONS OF ADOPTIVE TRANSFER

摘要

The present invention provides the sequences encoding the α and β chains of the transgenic TCR specific for the MHC class I/peptide hTERTB65-873 complex restricted for HLA-A02, which is physiologically expressed on the membrane of immortalised cancer cells, and the therapeutic use of transduced T lymphocytes in contrast the neoplastic progression.