HIV-1 V3 Mimotopes Capable of Inducing Cross-Clade Neutralizing Antibodies

摘要

The invention provides methods, compositions and kits for treating and or preventing an HIV infection. For example, HIV envelope-like polypeptides (wild-type HIV polypeptides and mimotopes) may be administered to an individual so as to induce a protective immune response to HIV. Alternatively, antibodies directed to the HIV envelope-like polypeptides may be administered to an individual to treat or prevent an HIV infection and/or one or more symptoms associated with the infection (e.g., AIDS).

主权项

1. An isolated HIV envelope-like polypeptide, wherein said polypeptide comprises an amino acid sequence which is 90% or more identical to an amino acid sequence selected from the group consisting of those recited in FIG. 1 or FIG. 9.