| 摘要 |
PROBLEM TO BE SOLVED: To provide a 1,2-disubstituted imidazole production method which can suppress production of by-products and efficiently produce high-purity 1,2-disubstituted imidazole in a shorter reaction time than that of the conventional one.SOLUTION: A 1,2-disubstituted imidazole production method includes a first stage reaction step of reacting an aldehyde compound with ammonia and/or a primary amine, and a second stage reaction step of reacting a glyoxal compound and ammonia and/or a primary amine with reaction products in the first stage reaction step. The primary amine is reacted in at least one of the first stage reaction step and the second stage reaction step to produce 1,2-disubstituted imidazole in a flow manner. The reaction in at least one of the first stage reaction step and the second stage reaction step is performed in a pressurized state at a pressure of 1-50 MPa.SELECTED DRAWING: Figure 1 |
