发明名称 |
Phosphorous-linked oligomeric compounds and their use in gene modulation |
摘要 |
Oligonucleotide compositions comprising first and second oligonucleotides are provided wherein at least a portion of the first oligonucleotide is capable of hybridizing with at least a portion of the second oligonucleotide, at least a portion of the first oligonucleotide is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligonucleotides includes at least one nucleotide having a modified phosphorous-containing internucleoside linkage. Oligonucleotide/protein compositions are also provided comprising an oligonucleotide complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligonucleotide has a modified phosphorous-containing internucleoside linkage.
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申请公布号 |
US2005042647(A1) |
申请公布日期 |
2005.02.24 |
申请号 |
US20040860455 |
申请日期 |
2004.06.03 |
申请人 |
BAKER BRENDA F.;ELDRUP ANNE B.;MANOHARAN MUTHIAH;BHAT BALKRISHEN;GRIFFEY RICHARD H.;SWAYZE ERIC E.;CROOKE STANLEY T.;PRAKASH THAZHA P. |
发明人 |
BAKER BRENDA F.;ELDRUP ANNE B.;MANOHARAN MUTHIAH;BHAT BALKRISHEN;GRIFFEY RICHARD H.;SWAYZE ERIC E.;CROOKE STANLEY T.;PRAKASH THAZHA P. |
分类号 |
A61K48/00;C07H21/02;C12Q1/68;(IPC1-7):A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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