发明名称 |
HUMAN APPLICATION OF ENGINEERED CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS |
摘要 |
The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment. |
申请公布号 |
US2016158285(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
US201414890977 |
申请日期 |
2014.05.14 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
COOPER Laurence JN;TORIKAI Hiroki;ZHANG Ling;HULS Helen;WANG-JOHANNING Feng;HURTON Lenka;OLIVARES Simon;KRISHNAMURTHY Janani |
分类号 |
A61K35/17;C07K14/54 |
主分类号 |
A61K35/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Austin TX US |