| 主权项 |
1. A method for diagnosing propensity to non-contact cranial cruciate ligament rupture (CCLR) in a dog, the method comprising:
(a) isolating genomic DNA from a dog; (b) analyzing the genomic DNA from step (a) for at least one single nucleotide polymorphism (SNP) occurring within, or in a genomic interval of about 2 Mb upstream or downstream of, at least one locus selected from the group consisting of: BICF2G630500368, BICF2P1121006, BICF2S2356299, BICF2P483191, BICF2P50610, BICF2P890246, BICF2S23324965, BICF2P544126, BICF2P526639, BICF2P1462185, BICF2P1208798, BICF2G630175389, BICF2S24415473, BICF2G630412697, BICF2P498515, BICF2P792911, BICF2G630810143, BICF2P564273, TIGRP2P297337, BICF2G630658881, BICF2G630709791, BICF2S23147946, BICF2P181859, BICF2G630712921, BICF2G630713147, BICF2P818099, BICF2S23638642, BICF2P206910, BICF2S22959529, BICF2P1054044, BICF2S23533020, BICF2P720951, TIGRP2P31530, BICF2P247448, BICF2P1066899, BICF2G630464857, BICF2G630108404, BICF2S23148483, BICF2P866702, BICF2P1109077, BICF2P1431921, BICF2P241884, BICF2P564273, TIGRP2P46522, BICF2G630349775, BICF2S2342150, BICF2S24415473, BICF2G630359517, BICF2G63058646, BICF2P295392, BICF2G630168473, BICF2G630175389, BICF2G630810143, BICF2G630810159, BICF2G630810173, BICF2P170661, BICF2P1354767, BICF2P205255, BICF2P1358119, BICF2S23324965, BICF2S22961650, BICF2P498515, BICF2P1072682, BICF2P1090079, BICF2P1208798, BICF2P890246, BICF2P139678, BICF2S23113199, BICF2P401973, BICF2P454456, BICF2P50610, BICF2P531097, BICF2P1290820, BICF2P65003, BICF2G630606359, BICF2S23620879, BICF2G630519882, BICF2P594418, BICF2G630422966, BICF2G630422956, BICF2G630422900, BICF2G630422895, BICF2P880005, BICF2P1121006, BICF2P888055, BICF2P582174, TIGRP2P270462, BICF2P716829, BICF2P1462185, BICF2P178583, BICF2S2328420, BICF2P420488, TIGRP2P277002, BICF2P111342, BICF2G630658881, BICF2G630658668, BICF2G630658620, BICF2G630658768, BICF2G630658756, BICF2G630658723, BICF2S2442023, BICF2S2361376, BICF2P321064, TIGRP2P293361, TIGRP2P297337, BICF2G630375268, BICF2S23730962, BICF2G630502225, BICF2G630500368, BICF2G630500363, BICF2G630500835, BICF2P544126, BICF2S24111418, BICF2G630799191, BICF2P792911, BICF2S2356299, BICF2P1332722, BICF2P1047447, BICF2P487060, BICF2P599881, BICF2P1410038, BICF2S23535135, TIGRP2P355298, BICF2S23255928, BICF2P526639, BICF2S23152419, BICF2P491441, TIGRP2P355396, BICF2P337576, BICF2P794117, BICF2P155064, BICF2P992747, BICF2S23652189, TIGRP2P362234, BICF2S23346408, BICF2S23713161, BICF2S23410873, BICF2P1135545, BICF2P483191, BICF2P139173, BICF2P361907, BICF2P456086, BICF2P662502, BICF2G630412697, BICF2S2356993, BICF2P287265, BICF2S23054250, BICF2P1086740, and BICF2P708698; (c) wherein the dog has an increased propensity for CCLR when five or more SNPs are detected in the dog's genomic DNA. |
