发明名称 |
NONHUMAN ANIMAL REPRODUCING PATHOGENIC CONDITIONS OF SPINAL AND BULBAR MUSCULAR ATROPHY AND REMEDY FOR SPINAL AND BULBAR MUSCULAR ATROPHY |
摘要 |
<p>It is intended to provide a model animal faithfully reproducing the pathogenic conditions of spinal and bulbar muscular atrophy, a method of screening a remedy for polyglutamine disease using the same, and a remedy for spinal and bulbar muscular atrophy. Namely, a nonhuman animal having the following characteristics (1) to (5) in its conditions or pathological findings: (1) showing progressive myoatrophy; (2) showing lowering in muscular power; (3) in immunostaining with the use of an anti-polyglutamine antibody, showing nuclear diffuse staining and nuclear inclusions; (4) in immunostaining with the use of an anti-androgen receptor antibody, showing nuclear diffuse staining and nuclear inclusions; and (5) showing a neurogenic change. A remedy for polyglutamine disease is screened by administering a test substance to this nonhuman animal and examining changes in its conditions or pathological findings. A remedy for spinal and bulbar muscular atrophy is prepared by using as the active ingredient a compound having an effect of inhibiting the secretion of testosterone. <IMAGE></p> |
申请公布号 |
EP1543722(A1) |
申请公布日期 |
2005.06.22 |
申请号 |
EP20030788136 |
申请日期 |
2003.08.18 |
申请人 |
NAGOYA INDUSTRIAL SCIENCE RESEARCH INSTITUTE |
发明人 |
SOBUE, GEN;KATSUNO, MASAHISA;ADACHI, HIROAKI |
分类号 |
A01K67/027;A61P5/28;A61P21/00;A61P25/00;A61P43/00;C12N15/85;G01N33/68;G01N33/74;(IPC1-7):A01K67/027;G01N33/15;A61K38/00;G01N33/50;A61K45/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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