发明名称 |
Diblock copolymers and polynucleotide complexes thereof for delivery into cells |
摘要 |
Diblock Copolymers And Polynucleotide Complexes Thereof For Delivery Into Cells Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic. |
申请公布号 |
AU2013204733(B2) |
申请公布日期 |
2016.06.16 |
申请号 |
AU20130204733 |
申请日期 |
2013.04.12 |
申请人 |
UNIVERSITY OF WASHINGTON;PHASERX, INC. |
发明人 |
HOFFMAN, ALAN S.;GALL, ANNA;CONVERTINE, ANTHONY J.;JOHNSON, PAUL;BENOIT, DANIELLE;STAYTON, PATRICK S.;DUVALL, CRAIG L. |
分类号 |
A61K48/00;C08F293/00;C08F299/00;C08F299/02;C08F299/04;C12N15/11;C12N15/87 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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