| 发明名称 |
PREVENTION OF TYPE 1 DIABETES BY TREG VACCINATION WITH AN INSULIN MIMETOPE |
| 摘要 |
The invention involves methods and products for inducing Treg cells for immune suppression in connection with autoimmune disease and transplant rejection. |
| 申请公布号 |
US2016175412(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201514834665 |
申请日期 |
2015.08.25 |
| 申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
VON BOEHMER HARALD;DANIEL CAROLIN |
| 分类号 |
A61K39/00;A61K47/48 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for increasing in a subject Treg cells specific for an antigen, comprising
administering to the subject, under sub-immunogenic conditions, a mimetope of the antigen, wherein the mimetope has a mimetope TCP index, and wherein the mimetope TCP index is at least 25% greater than the antigen TCP index under the same conditions of T cell proliferation. |
| 地址 |
BOSTON MA US |
