发明名称 |
ANTIBACTERIAL ANTISENSE OLIGONUCLEOTIDE AND METHOD |
摘要 |
A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3′ or 5′ end of the oligonucleotide and modifying the oligonucleotide to contain 20%-50% intersubunit linkages that are positively charged at physiological pH. Also disclosed is an antisense oligonucleotide having enhanced antibacterial activity by virtue of one or both modifications. |
申请公布号 |
US2016251398(A1) |
申请公布日期 |
2016.09.01 |
申请号 |
US201514977451 |
申请日期 |
2015.12.21 |
申请人 |
Sarepta Therapeutics, Inc. |
发明人 |
Weller Dwight D.;Geller Bruce L.;Iversen Patrick L.;Tilley Lucas D.;Hassinger Jed N. |
分类号 |
C07K7/02 |
主分类号 |
C07K7/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Corvallis OR US |