发明名称 |
COMBINATION THERAPY FOR TREATMENT OF CANCER |
摘要 |
Described herein are combination therapies for the treatment of cancer and other diseases. In one aspect, the methods described herein for the treatment of cancer and other diseases comprise administering a RSPO-LGR pathway inhibitor in combination with a mitotic inhibitor. The present invention relates to methods of treating cancer comprising administering to a subject a therapeutically effective amount of an RSPO-LGR pathway inhibitor, such as an antiRSP03 antibody or anti-LGR5 antibody. In certain embodiments, the methods further comprise administration of a mitotic inhibitor to the patient. In certain embodiments the RSPO-LGR pathway inhibitor is administered about 1 day, about 2 days, or about 3 days prior to the mitotic inhibitor. |
申请公布号 |
WO2016090024(A4) |
申请公布日期 |
2016.09.22 |
申请号 |
WO2015US63480 |
申请日期 |
2015.12.02 |
申请人 |
ONCOMED PHARMACEUTICALS, INC. |
发明人 |
GURNEY, Austin;YEN, Wan-Ching;HOEY, Timothy Charles |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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