METHODS OF ATTENUATING PROSTATE TUMOR GROWTH BY INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 (IGFBP-3)
摘要
Insulin-like Growth Factor Binding Protein - 3 (IGFBP-3) inhibits cell growth and promotes apoptosis by sequestering free Insulin-like Growth Factor (IGF), and also demonstrates IGF-independent, pro-apoptotic, anti-proliferative effects on prostate cancer cells. Prostate tumor size was significantly attenuated in transgenic mice over-expressing IGFBP-3 compared with wild-type mice. In addition, a marked reduction in late-stage tumor growth was apparent in transgenic mice over expressing mutant-IGFBP-3 indicating that the IGF-independent effects of IGFBP-3 are related to inhibiting tumor progression.
申请公布号
WO2007022635(A3)
申请公布日期
2007.04.19
申请号
WO2006CA01395
申请日期
2006.08.23
申请人
THE UNIVERSITY OF MANITOBA;SILHA, JOSEF;DODD, JANICE, G.;MURPHY, LIAM, J.