Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

摘要

This invention provides compounds of the formula:
wherein: X is a chemical bond, -CH 2 - or -C(O)- ; R 1 is alkyl, cycloalkyl, -CH 2 -cycloalkyl, pyridinyl, -CH 2 -pyridinyl, phenyl or benzyl; R 2 is H, alkyl, cycloalkyl, -CH 2 -cycloalkyl, or perfluoroalkyl; R 3 is H, halo, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, -CH 2 -cycloalkyl, -NH 2 , or -NO 2 ; R 4 is optionally substituted phenyl, benzyl, benzyloxy, pyridinyl, or -CH 2 -pyridinyl, or the salt or ester forms thereof; as well as methods for using the compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) ; and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis; and processes for their preparation.