发明名称 |
SERUM ALBUMIN BINDING PEPTIDES FOR TUMOR TARGETING |
摘要 |
Peptide ligands having affinity for serum albumin are useful for tumor targeting. Conjugate molecules comprising a serum albumin binding peptide fused to a biologically active molecule demonstrate modified pharmacokinetic properties as compared with the biologically active molecule alone, including tissue (e.g., tumor) uptake, infiltration, and diffusion. |
申请公布号 |
US2016185874(A1) |
申请公布日期 |
2016.06.30 |
申请号 |
US201514825114 |
申请日期 |
2015.08.12 |
申请人 |
GENENTECH, INC. |
发明人 |
Dennis Mark S. |
分类号 |
C07K16/30;C07K7/08 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
|
主权项 |
1. A method for modulating tissue distribution of a peptide molecule, comprising administering to the tissue a conjugate molecule comprising a peptide ligand domain and an active domain, wherein the peptide ligand domain comprises a serum albumin binding peptide and the active domain comprises the peptide molecule; and wherein said administering of the conjugate molecule results in tissue distribution of the peptide molecule that differs from that obtained on administration of the active domain alone. |
地址 |
South San Francisco CA US |