发明名称 |
PDK1 BINDING MOLECULES AND USES THEREOF |
摘要 |
The present invention is based, at least in part, on the discovery that PDK1 is associated with the outer plasma membrane of the cell. Accordingly, the present invention encompasses 3-phosphoinositide-dependent protein kinase-1 (PDK1) binding molecules, such as an antibody. The binding molecules of the invention are useful for detecting PDK1 and for inhibiting PDK1 activity, e.g., in a human subject having a disorder in which PDK1 activity is detrimental, such as a cancer. |
申请公布号 |
WO2016090365(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
WO2015US64285 |
申请日期 |
2015.12.07 |
申请人 |
DESSAIN, SCOTT, KENDALL;HEIMBACH, BARON, CHRISTOPHER |
发明人 |
DESSAIN, SCOTT, KENDALL;HEIMBACH, BARON, CHRISTOPHER |
分类号 |
A61K39/395;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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