发明名称 |
METHOD FOR PRODUCING POLYPEPTIDE HETEROMULTIMER |
摘要 |
It is intended to provide a method for efficiently and stably producing a heteromultimer by incubating, under a reducing condition, homo variants of plural types of polypeptides in which the alteration of amino acids that form the interface between Fc regions and/or the alteration to destabilize the stability of a heavy chain CH3 region has been introduced in the heavy chain CH3 regions so at to achieve the promotion of the dissociation of the Fc regions and/or the control of the association thereof through the use of charge repulsion. |
申请公布号 |
EP3050896(A1) |
申请公布日期 |
2016.08.03 |
申请号 |
EP20140847811 |
申请日期 |
2014.09.26 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;KATADA, HITOSHI;MIMOTO, FUTA |
分类号 |
C07K16/00;A61K39/395;A61P35/00;C12N15/09 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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