Non-Nucleotide Reverse Transcriptase Inhibitors

摘要

Compounds of the formula Z: where; A is CH or N; R₁ is a substituent to a carbon atom in the ring containing A selected from -S(-O)_pRa, where Ra is -C₁-C₄ alkyl, -ORx, -NRxRx, -NHNRxRx, -NHNHC(-O)ORx, -NRxOH; -C(-O)-Rb, where Rb is -CT-C4-alkyl, ORx, -NRxRx, -NHNRxRx, -NHC₁-C₃-alkyl-C(-O)Orx -NRxRc, where Rc is H, C₁-C₄ alkyl, -NRxRx; -C(=0)Rd, -CN, S(-O)pRx, where Rd is Rd is C1-C4-alkyl, -ORx, -NRxRx C₁-C₃-alkyl-O-C1-C3-alkylC(-O)ORx, -C₁-C₃-alkyl-COORx; -C₁-C₃alkyl-OH or C₁-C₄ alkyl ethers or esters thereof (O-C₁-C₃alkyl)q-O-Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C₁-C₄ alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -O -, -S(-O)-, or -CH₂-, where r is 0, 1 or 2; R₃-R₇ are substituents as defined in the specification; X is -(CR₈R₈')n-D-(CR₈R₈')m-; D is a bond, -NR₉-, -O-, -S-, -S(=0)- or -S(=0)₂-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals.