TRIAZOLE DERIVATIVE OR SALT THEREOF

摘要

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), particularly diabetes or insulin resistance. [MEANS FOR SOLVING PROBLEMS] Disclosed is a triazole derivative which has a triazole ring substituted by a 3-substituted methyl group at position-3 and further substituted by a lower alkyl, a cycloalkyl or the like at position-5, or a pharmaceutically acceptable salt thereof. It is found that the triazole derivative or the salt thereof has a potent inhibitory activity on 11beta-HSD1. The triazole derivative has an excellent anti-hyperglycemic activity and therefore can be used for the treatment of diabetes or insulin resistance. ® KIPO & WIPO 2009