发明名称 |
Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating HCV infections |
摘要 |
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula (I) D-M-D (Formula I) useful as antiviral agents. In certain embodiments disclosed herein M is a group -P-A-P- where A is (Formula I) Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/ and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure. |
申请公布号 |
AU2012262338(B2) |
申请公布日期 |
2016.12.08 |
申请号 |
AU20120262338 |
申请日期 |
2012.05.29 |
申请人 |
Achillion Pharmaceuticals, Inc. |
发明人 |
Wiles, Jason Allan;Wang, Qiuping;Hashimoto, Akihiro;Pais, Godwin;Chen, Dawei;Wang, Xiangzhu;Gadhachanda, Venkat;Phadke, Avinash;Deshpande, Milind |
分类号 |
C07D403/14;A61K31/4164;A61K31/4178;A61P31/00;A61P31/12 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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