发明名称 |
SYNTHESIS AND PARTICLE ENGINEERING OF COCRYSTALS |
摘要 |
The present invention discloses a scalable and solvent-free method to produce cocrystals in a particulate form. A method of making cocrystals comprises the steps of: a) feeding a molten mixture of at least a first substance and a second substance which are able to form cocrystals to an atomizer; b) atomizing the molten mixture to droplets; c) solidifying the droplets to particles; d) collecting the said particles. The invention also provides the use of cocrystals made according to the method of the invention in the formulation of a pharmaceutical composition. The invention also provides cocrystals obtainable or obtained by the method of the present invention, in particular cocrystals in the form of particles. Also provided is a pharmaceutical composition comprising cocrystals made according to the method of the invention, in particular, a pharmaceutical composition comprising cocrystals in the form of particles made according to the method of the invention. |
申请公布号 |
EP3046546(A1) |
申请公布日期 |
2016.07.27 |
申请号 |
EP20140772421 |
申请日期 |
2014.09.16 |
申请人 |
HOVIONE INTERNATIONAL LTD. |
发明人 |
DUARTE, IRIS;PEREIRA, MARIA JOSÉ;PADRELA, LUIS;TEMTEM, MÁRCIO |
分类号 |
A61K9/16;B01D9/00 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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